Protein-sphingolipid interactions within cellular membranes
نویسندگان
چکیده
منابع مشابه
Protein-sphingolipid interactions within cellular membranes.
Each intracellular organelle critically depends on maintaining its specific lipid composition that in turn contributes to the biophysical properties of the membrane. With our knowledge increasing about the organization of membranes with defined microdomains of different lipid compositions, questions arise regarding the molecular mechanisms that underlie the targeting to/segregation from microdo...
متن کاملLipid-protein interactions in membranes.
The interactions of lipids with integral and peripheral proteins can be studied in reconstituted and natural membranes using spin label electron spin resonance (ESR) spectroscopy. The ESR spectra reveal a reduction in mobility of the spin-labelled lipid species, and in certain cases evidence is obtained for a partial penetration of the peripheral proteins into the membrane. The latter may be re...
متن کاملShape matters in protein mobility within membranes.
The lateral mobility of proteins within cell membranes is usually thought to be dependent on their size and modulated by local heterogeneities of the membrane. Experiments using single-particle tracking on reconstituted membranes demonstrate that protein diffusion is significantly influenced by the interplay of membrane curvature, membrane tension, and protein shape. We find that the curvature-...
متن کاملStudies using lectins to determine mineral interactions with cellular membranes.
Chrysotile asbestos interacts with mucin-secreting cells of tracheal organ cultures, causing an increase in secretion of mucin into the culture medium. This response occurs in the absence of obvious morphologic damage to tracheal epithelial cells. We speculated that asbestos-induced hypersecretion was regulated by the interaction of fibers with specific carbohydrate residues on the cell surface...
متن کاملInteractions of phorbol esters with cellular membranes in vitro.
Esters of phorbol, a family of tumor-promoting agents, interact in vitro with cellular membranes. In CsCl equi librium density gradients, isotopically labeled phorbol didecanoate cosediments with microsomal and nuclear membranes prepared from rat liver. The interaction be tween these membranes and the promoting compound is enhanced in the presence of native or denatured DNA. Moreover, changes i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2008
ISSN: 0022-2275
DOI: 10.1194/jlr.d700023-jlr200